Kate McCann, Mother of missing British girl Madeleine McCann, questioned by Police

Such a sad story, but it is about time they question the mother again!

CNN REPORTS: "(CNN) -- The mother of Madeleine McCann was interviewed by Portuguese police for a second time on Thursday amid reports of a possible forensic breakthrough in the hunt for the missing British four-year-old girl.

Four-year-old Madeleine McCann has been missing since disappearing from a Portuguese holiday apartment in early May.

The UK's Press Association reported Thursday that the UK-based Forensic Science Service (FSS) had uncovered "significant new information" after analyzing evidence taken from the holiday apartment in Praia da Luz, Portugal, from which Madeleine disappeared.

Specks of blood, items of clothing and other objects in the apartment were being tested.

Portuguese police said they were now giving special attention to the theory that Madeleine, who has been missing since early May, was dead, PA reported.

But a spokeswoman for the FSS told PA that tests were ongoing: "There has been no change in that, despite what the reports say. It's a live investigation and we are working with the police."

Meanwhile mother Kate McCann appealed for those responsible for her daughter's disappearance to release her or call the police, as she arrived at a police station in Portimao for questioning on Thursday afternoon, according to PA.

Kate McCann was previously interviewed on May 4, the day after Madeleine was reported missing. Her husband, Gerry McCann, who has already been interviewed twice, was due to speak to police on Friday.

"I miss Madeleine so much," said Kate McCann in a statement. "Gerry and I want to appeal again to the person or people who took her or know who took her to do the right thing.

"It is not too late - please let her go or call the police. We came to Portugal an ordinary family of five. We just want to know what happened on May 3 and want to be able to go home one family, reunited."

Justine McGuinness, the McCanns' spokeswoman, said in a statement they were happy to assist the police with their inquiries.

"Today Kate McCann has returned to Portimao to be questioned by the Portuguese police to assist them in their investigations," the statement said.

"Kate and Gerry are happy to help the police in their investigations to find their daughter Madeleine, as they have been since she was taken. Kate continues to believe that Madeleine is still alive, and to hope and pray that she will be returned soon.

"Kate is a loving, gentle mother - one of the victims in an extraordinary and terrible set of events."